In the field of nanotechnology, SPAAC is significant for its ability to create highly specific and stable covalent bonds under mild conditions. This feature is essential for the functionalization of nanomaterials, where maintaining the integrity and functionality of both the nanomaterial and the biomolecule is crucial. SPAAC enables the precise modification of nanoparticles, nanotubes, and other nanostructures, enhancing their utility in drug delivery, imaging, and biosensing.
