What is Strain Promoted Azide Alkyne Cycloaddition (SPAAC)?
Strain Promoted Azide Alkyne Cycloaddition (SPAAC) is a type of click chemistry that facilitates the rapid and efficient conjugation of azides and alkynes without the need for a copper catalyst. The reaction relies on the ring strain of cyclic alkynes, such as dibenzocyclooctyne (DIBO), which accelerates the cycloaddition with azides.
