Despite its importance, direct measurement at the nanoscale presents several challenges:
1. Resolution Limits: Achieving the necessary resolution to observe individual atoms or molecules can be difficult. 2. Sample Preparation: Preparing samples without altering their inherent properties is often challenging. 3. Environmental Sensitivity: Nanomaterials can be highly sensitive to environmental conditions such as temperature and humidity, which can affect measurement accuracy. 4. Instrumentation Costs: The equipment required for direct measurement, such as AFM and TEM, can be very expensive and require specialized training to operate.
