The principle behind click chemistry involves the use of modular building blocks that can "click" together in a predictable manner. The most common type of reaction used in click chemistry is the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC). This reaction connects an azide and an alkyne to form a 1,2,3-triazole ring. The reaction is fast, efficient, and can proceed under mild conditions, making it suitable for synthesizing complex nanostructures.