What are the Challenges in Using Endosomes for Drug Delivery?
One of the primary challenges in utilizing endosomes for drug delivery is ensuring the nanoparticles can escape the endosome to release their therapeutic cargo in the cytoplasm. Additionally, avoiding premature degradation in the lysosome and achieving precise targeting to specific intracellular compartments are significant hurdles. Researchers are continuously exploring new materials and mechanisms to overcome these challenges.
