The core mechanism involves the encapsulation of siRNA within nanoparticles, which protect the siRNA from degradation and facilitate its delivery to the target cells. Upon reaching the target cell, the nanoparticles are taken up via endocytosis, and the siRNA is released into the cytoplasm. This siRNA then incorporates into the RNA-induced silencing complex (RISC), guiding the complex to the complementary mRNA, which is subsequently degraded, thus preventing protein synthesis.
