What Are the Advantages of Using siRNA Loaded Nanoparticles?
Using nanoparticles for siRNA delivery offers multiple advantages: 1. Protection from Degradation: siRNA molecules are highly susceptible to degradation by nucleases in the bloodstream. Encapsulation within nanoparticles shields them from enzymatic attack. 2. Targeted Delivery: Nanoparticles can be engineered to target specific tissues or cells, enhancing the efficacy and reducing off-target effects. 3. Controlled Release: The release of siRNA can be controlled over time, improving the therapeutic outcome. 4. Enhanced Cellular Uptake: Nanoparticles improve the cellular uptake of siRNA, ensuring efficient gene silencing.
