What Are the Challenges in Using siRNA Loaded Nanoparticles?
Despite their potential, several challenges must be addressed: 1. Stability: Ensuring the stability of siRNA within the nanoparticles and in biological environments. 2. Immunogenicity: Minimizing the immune response against the nanoparticles. 3. Off-Target Effects: Achieving precise targeting to reduce unintended gene silencing. 4. Scalability: Developing cost-effective and scalable manufacturing processes.
