Engineering Surface Properties: Modifying surface properties to improve interaction with biological molecules and facilitate quicker clearance. Targeted Delivery: Designing nanoparticles to target specific cells or tissues, minimizing off-target accumulation. Biodegradable Materials: Using materials that naturally degrade into non-toxic byproducts can enhance clearance. Real-Time Monitoring: Developing techniques for real-time monitoring of nanoparticle distribution and clearance in vivo.