Several factors can influence how nanoparticles are cleared from the body:
Size: Smaller nanoparticles are more likely to be cleared via renal pathways, while larger ones are typically processed by the liver. Shape: The shape of a nanoparticle can affect its circulation time and uptake by immune cells. Surface Chemistry: Functional groups on the nanoparticle surface can interact with biological molecules, affecting clearance. Charge: Positively charged nanoparticles are generally cleared faster, as they are more readily taken up by cells. Hydrophobicity: More hydrophobic nanoparticles tend to accumulate in the liver and spleen.
