What Strategies are Employed to Enhance EPR Effect?
Researchers are exploring multiple strategies to enhance the EPR effect and improve nanoparticle delivery:
Combination Therapy: Using EPR-based nanoparticles in conjunction with other treatments, such as anti-angiogenic agents, to normalize tumor vasculature and improve permeability. Stimuli-responsive Nanoparticles: Designing nanoparticles that respond to specific stimuli (e.g., pH, temperature) to release their payload precisely at the tumor site. Active Targeting: Conjugating nanoparticles with ligands or antibodies that specifically bind to tumor cell receptors, enhancing selective uptake.
