What are the Challenges Associated with EPR-based Nanoparticle Delivery?
Despite its potential, several challenges hinder the efficiency of EPR-based nanoparticle delivery:
Heterogeneity of Tumors: The EPR effect varies significantly among different tumors and even within the same tumor, leading to inconsistent delivery. Limited Penetration: While nanoparticles can accumulate in the vicinity of the tumor, penetrating deep into the tumor tissue remains challenging. Clearance Mechanisms: The body's natural defense mechanisms, such as the mononuclear phagocyte system, can clear nanoparticles before they reach the tumor site.
