What are the Key Features of Nanoparticles Utilized for EPR?
Nanoparticles designed to exploit the EPR effect typically possess the following features:
Size: Ideal nanoparticles range from 10 to 200 nm, large enough to avoid renal clearance but small enough to penetrate tumor vasculature. Surface Modification: Surface properties, such as charge and hydrophilicity, are tailored to improve circulation time and reduce opsonization by the immune system. Biocompatibility: Materials like liposomes, dendrimers, and polymeric nanoparticles are commonly used due to their biocompatibility and ability to encapsulate therapeutic agents.
