What factors influence the in vivo distribution of nanoparticles?
The distribution of nanoparticles within a living organism is influenced by several factors:
1. Size and shape: Smaller nanoparticles can penetrate tissues more easily, while elongated shapes might have different distribution patterns compared to spherical ones. 2. Surface properties: The surface charge and hydrophobicity of nanoparticles affect their interaction with biological membranes and proteins. 3. Functionalization: Modifying the surface with specific ligands or polymers can target nanoparticles to specific cells or tissues, enhancing their therapeutic efficacy.
