What are some strategies to improve the in vivo performance of nanoparticles?
Several strategies can be employed to improve the in vivo performance of nanoparticles:
1. Surface modification: Coating nanoparticles with biocompatible polymers, such as polyethylene glycol (PEG), can reduce protein adsorption and increase circulation time. 2. Targeting ligands: Attaching specific ligands to the nanoparticle surface can target them to particular cells or tissues, enhancing their therapeutic efficacy. 3. Controlled release: Designing nanoparticles with controlled release mechanisms can ensure a sustained and localized release of therapeutic agents, minimizing side effects.
