What Factors Influence Cell Uptake of Nanoparticles?
Multiple factors affect the efficiency and extent of nanoparticle uptake by cells:
Size: Smaller nanoparticles are generally internalized more efficiently. Shape: Rod-shaped nanoparticles might be taken up differently than spherical ones. Surface Charge: Positively charged nanoparticles often interact more readily with negatively charged cell membranes. Surface Modification: Functionalizing nanoparticles with specific ligands can enhance targeted uptake. Cell Type: Different cells have varying capacities and mechanisms for nanoparticle uptake.
These factors must be carefully considered during the nanoparticle design process to achieve desired cellular interactions.
