Several factors contribute to burst release in nanotechnology: - Surface Adsorption: Drugs adsorbed on the surface of the nanoparticles are released quickly. - Matrix Degradation: Rapid degradation of the carrier matrix can lead to a quick release of the encapsulated drug. - Diffusion: High concentration gradients between the nano-carrier and the surrounding environment can drive a rapid initial release. - Particle Size and Shape: Smaller and irregularly shaped nanoparticles tend to show higher burst release due to their large surface area.
