Controlling burst release is essential for achieving desired therapeutic outcomes. Several strategies can be employed: - Surface Modification: Coating nanoparticles with polymers or surfactants can reduce the initial burst by limiting surface adsorption. - Cross-linking: Increasing the degree of cross-linking in the polymer matrix can slow down the degradation and diffusion of the drug. - Encapsulation Efficiency: Enhancing the encapsulation efficiency ensures that less drug is available on the surface for immediate release. - Layer-by-Layer Assembly: This technique involves constructing multilayered nanoparticles that can control the release profile more precisely.
