What are the Methods for Synthesizing PLGA Nanoparticles?
Several techniques are used to synthesize PLGA nanoparticles, each with its advantages and limitations. Common methods include:
Emulsification-Solvent Evaporation: This method involves dissolving PLGA and the drug in an organic solvent, followed by emulsification in an aqueous phase and subsequent solvent evaporation. Nanoprecipitation: In this method, PLGA and the drug are dissolved in a water-miscible solvent and then added to an aqueous phase, causing the polymer to precipitate and form nanoparticles. Spray Drying: This technique involves spraying a solution of PLGA and the drug through a nozzle to form fine droplets, which are then dried to form nanoparticles.
