Several tests are conducted to evaluate hemocompatibility:
- Hemolysis Assay: This test determines if the nanoparticles cause the rupture of red blood cells, releasing hemoglobin into the plasma. - Platelet Aggregation: This assesses whether the nanoparticles induce the clumping together of platelets, which could lead to clot formation. - Coagulation Tests: These include assays like the Prothrombin Time (PT) and Activated Partial Thromboplastin Time (aPTT) to evaluate the effect of nanoparticles on the blood clotting process. - Complement Activation: This test checks if the nanoparticles activate the complement system, a part of the immune response, leading to inflammation. - Cytokine Release: This measures the release of cytokines, which are signaling proteins in the immune system, in response to nanoparticle exposure.
