What Are the Challenges in Hemocompatibility Testing?
Several challenges are unique to nanotechnology:
- Surface Chemistry: The surface properties of nanoparticles can significantly affect their interactions with blood components. Modifying these surfaces to enhance compatibility without altering their functional properties is challenging. - Size and Shape: The nanoscale dimensions and various shapes of nanoparticles can lead to different biological interactions, complicating standardization. - Dosage: Determining the appropriate and safe dosage of nanoparticles is difficult due to their high surface area to volume ratio, which can result in a higher reactivity compared to bulk materials.
