PEGylation offers several benefits that are particularly valuable in nanotechnology:
Increased circulation time: PEGylated nanoparticles evade detection and clearance by the immune system, allowing them to remain in the bloodstream longer. Enhanced biocompatibility: The hydrophilic nature of PEG reduces interactions with biological components, minimizing potential toxicities. Improved solubility: PEGylation can increase the solubility of hydrophobic drugs, facilitating their delivery. Controlled release: PEGylation can be tailored to control the release rate of therapeutics from nanoparticles.
