PEGylation is particularly significant in the field of nanomedicine, especially for drug delivery systems. When conjugated with drug-carrying nanoparticles, PEG helps in reducing their immunogenicity and prolonging their circulation time in the bloodstream. This is because PEG creates a hydrophilic barrier around the nanoparticles, preventing their recognition and clearance by the immune system. Thus, PEGylated nanoparticles can deliver drugs more effectively to target sites, enhancing therapeutic outcomes.
