What Factors Influence the Toxicology of Nanomaterials?
Several factors influence the toxicological profiles of nanomaterials:
Size and Shape: Smaller particles can penetrate biological membranes more easily, and their shape can influence cellular uptake and distribution. Surface Area and Chemistry: Larger surface areas can lead to more significant reactivity and interactions with biological molecules. Surface modifications can alter toxicity. Solubility and Aggregation: Soluble nanoparticles can release ions that may be toxic, while aggregation can influence particle distribution and bioavailability. Dose and Exposure Duration: Higher doses and longer exposure times typically increase the potential for toxic effects.
