What Factors Influence Nanoparticle Uptake and Localization?
Several factors can impact the uptake and localization of nanoparticles: 1. Size and Shape: Smaller nanoparticles are generally taken up more readily, while the shape can influence cellular interactions. 2. Surface Charge: Positively charged nanoparticles often exhibit higher uptake due to interactions with negatively charged cell membranes. 3. Surface Coating: Modifying the surface with specific ligands can enhance targeting and reduce non-specific interactions. 4. Aggregation: Aggregated nanoparticles may exhibit different uptake and localization patterns compared to dispersed particles.
