What Factors Influence Immunogenicity of Nanomaterials?
Several factors can influence the immunogenicity of nanomaterials:
Size and Shape: Smaller nanoparticles are generally more likely to be taken up by immune cells, potentially leading to a higher immune response. Surface Properties: The surface chemistry, charge, and functional groups of nanoparticles can affect their interaction with immune cells. Composition: The material from which nanoparticles are made can also determine their immunogenic potential. For example, some metals and polymers are more biocompatible than others. Coatings and Modifications: Surface modifications such as PEGylation can help reduce immunogenicity by preventing protein binding and recognition by the immune system.
