What are the Strategies to Mitigate Immunogenicity?
To mitigate immunogenicity, researchers employ several strategies:
Surface Functionalization: Modifying the nanoparticle surface with biocompatible materials can reduce immune recognition. Use of Biodegradable Materials: Utilizing materials that degrade into non-toxic by-products can minimize long-term immune responses. Immune Tolerance Induction: Pre-treating the body with small doses of the nanoparticle can sometimes induce immune tolerance. Encapsulation: Encapsulating drugs within nanoparticles can shield them from the immune system, reducing immunogenicity.
