Several factors can affect how nanoparticles distribute within a biological system:
Size: Smaller nanoparticles often circulate longer and penetrate tissues more easily than larger ones. Shape: The shape of a nanoparticle can influence its cellular uptake and distribution. For example, rod-shaped particles may behave differently from spherical ones. Surface Chemistry: Functionalization of the nanoparticle's surface with specific ligands or molecules can enhance its targeting capabilities. Charge: The surface charge of nanoparticles can affect their interaction with cells and proteins, influencing their biodistribution.
