Several factors can influence the hydrodynamic diameter of nanoparticles:
Surface Chemistry: Modifications to the surface of nanoparticles, such as functionalization with different molecules or polymers, can significantly alter the hydrodynamic diameter. Solvent Properties: The type of solvent and its properties, such as viscosity and ionic strength, can affect the measurement of the hydrodynamic diameter. Temperature: Changes in temperature can influence the viscosity of the solvent and the Brownian motion of the particles, thus affecting the hydrodynamic diameter.