Despite their advantages, the use of thiol groups in nanotechnology presents several challenges:
Stability Issues: The thiol-metal bond, while strong, can sometimes be unstable, especially in harsh chemical environments, leading to potential degradation of the functionalized surface. Oxidation: Thiol groups are susceptible to oxidation, which can alter their functionality and limit their application lifespan. Complexity in Synthesis: The synthesis of thiol-functionalized nanoparticles and their precise characterization can be complex and costly.
