Various regulatory frameworks have been established to ensure the safe use of nanotechnology: - REACH (Registration, Evaluation, Authorisation, and Restriction of Chemicals): This European Union regulation addresses the production and use of chemical substances, including nanomaterials. - TSCA (Toxic Substances Control Act): In the United States, this act regulates the introduction of new or already existing chemicals. - ISO Standards: The International Organization for Standardization has developed standards for the safe handling and use of nanomaterials.