What Are the Mechanisms of Penetration Enhancement?
Nanoscale carriers enhance drug penetration through several mechanisms:
Stratum Corneum Disruption: Nanocarriers can disrupt the outermost layer of the skin to facilitate drug entry. Follicular Pathway: Nanoparticles can penetrate through hair follicles, providing a direct route to deeper skin layers. Intercellular Pathway: Nanoscale carriers can navigate through the tiny spaces between skin cells.
