single molecule detection

How Does Single Molecule Detection Work?

There are several methods for SMD, including fluorescence microscopy, atomic force microscopy (AFM), and nanopore technology. These techniques often involve labeling molecules with fluorescent tags, applying mechanical forces, or measuring electrical conductance changes, respectively. Advanced optical setups, such as total internal reflection fluorescence microscopy (TIRFM) and super-resolution microscopy, enable the visualization of individual molecules.

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