What Are the Key Factors Influencing Nanoparticle-Cell Interactions?
Size: Smaller nanoparticles (typically below 100 nm) are more easily taken up by cells compared to larger particles. Shape: The shape of nanoparticles (spherical, rod-like, etc.) affects their cellular uptake and distribution. For instance, rod-shaped particles have been found to have enhanced cellular uptake compared to spherical ones. Surface Charge: Positively charged nanoparticles tend to interact more readily with negatively charged cell membranes, facilitating uptake. Surface Functionalization: Functionalizing nanoparticles with specific ligands can target them to specific cells or tissues, enhancing their efficacy.
