While in situ analysis offers numerous advantages, it also presents several challenges:
- Environmental Control: Maintaining the exact conditions required for in situ analysis can be difficult, especially when dealing with reactive or unstable nanomaterials. - Instrument Sensitivity: The high sensitivity of the instruments used can lead to issues with noise and signal interference, requiring advanced techniques to filter out unwanted data. - Data Interpretation: The data obtained from in situ analysis is often complex and requires sophisticated modeling and interpretation methods to draw meaningful conclusions.