Despite its advantages, cryomilling also presents some challenges: 1. Cost: The process can be expensive due to the need for liquid nitrogen and specialized equipment. 2. Complexity: The setup and operation of cryomilling apparatus require technical expertise. 3. Contamination: There is a risk of contamination from the milling media and environment, which can affect the quality of the nanoparticles. 4. Scale-Up: Scaling up from laboratory to industrial scale can be challenging and may require significant adjustments in process parameters.
