Several challenges exist in the toxicological testing of nanoparticles, including:
- Characterization: Accurate characterization of nanoparticles' properties, such as size, shape, surface charge, and chemical composition, is essential for interpreting toxicity data. - Standardization: Lack of standardized testing protocols and guidelines, resulting in variability in test results. - Dose Metrics: Determining appropriate dose metrics (e.g., mass, surface area, particle number) for toxicity assessment. - Complex Interactions: Nanoparticles may interact with biological systems in complex ways, making it difficult to predict their toxicological outcomes.
