What are the Challenges in Single Particle Spectroscopy?
Despite its advantages, single particle spectroscopy faces several challenges:
Signal-to-Noise Ratio: Detecting signals from individual particles often requires highly sensitive equipment and techniques to minimize background noise. Sample Preparation: Preparing samples that are suitable for single particle analysis can be difficult. Ensuring that particles are well-dispersed and not aggregated is crucial. Instrumentation: High-resolution and sensitive instruments are required, which can be expensive and complex to operate.
