What are the Challenges in QSAR for Nanotechnology?
Developing QSAR models for nanomaterials presents unique challenges:
1. Complexity: Nanomaterials have complex structures that are difficult to represent using traditional descriptors. 2. Data Scarcity: There is a lack of comprehensive and high-quality data on the properties of nanomaterials. 3. Size and Shape: Unlike small molecules, the size, shape, and surface properties of nanomaterials significantly influence their activity. 4. Mechanisms of Action: The mechanisms by which nanomaterials exert their effects can be different from those of small molecules.
