Conducting nanoscale analysis comes with several challenges:
Sample Preparation Preparing samples for techniques like TEM can be intricate and time-consuming, requiring extremely thin specimens.
Instrumentation Costs High-resolution instruments such as TEM and AFM are expensive to purchase and maintain, posing a barrier for some research institutions.
Data Interpretation Interpreting data at the nanoscale requires significant expertise and can be complicated by factors like artifacts introduced during sample preparation or analysis.