Despite its benefits, exfoliation faces several challenges:
Scalability While some methods, like liquid phase exfoliation, are scalable, others are not easily adapted for large-scale production.
Purity and Quality Maintaining the purity and quality of exfoliated layers can be difficult, with contaminants and defects often introduced during the process.
Reproducibility Achieving consistent results across different batches remains a challenge, affecting the reliability of exfoliated materials for industrial applications.