What are the Challenges Associated with PEGylation?
Despite its numerous advantages, PEGylation is not without challenges: 1. Heterogeneity: The PEGylation process can result in a heterogeneous mixture of PEGylated and non-PEGylated nanoparticles. 2. Cost: The synthesis and purification of PEGylated nanoparticles can be expensive. 3. Immunogenicity: In some cases, repeated administration of PEGylated nanoparticles can lead to the development of anti-PEG antibodies.
