What are the Advantages of Cryo-EM Over Other Imaging Techniques?
Compared to traditional imaging techniques like X-ray crystallography and nuclear magnetic resonance (NMR) spectroscopy, cryo-EM offers several advantages:
Minimal Sample Preparation: Samples can be studied in their native state without extensive preparation that may alter their structure. High Resolution: Cryo-EM can achieve near-atomic resolution, making it possible to visualize the fine details of nanostructures. Versatility: It is suitable for a wide range of samples, including large complexes, individual nanoparticles, and biological macromolecules.
