What Are Some Key Considerations When Using the Micronucleus Test for Nanomaterials?
1. Particle Characterization: It is essential to thoroughly characterize the nanomaterial, including its size, shape, surface charge, and chemical composition, as these factors can influence genotoxicity. 2. Dose-Response Relationship: Establishing a clear dose-response relationship helps in understanding the threshold levels for genotoxic effects. 3. Interaction with Biological Systems: Understanding how nanoparticles interact with cellular components, such as membranes and organelles, is crucial for interpreting the results accurately.
