There are several techniques to prepare nanosuspensions, including:
1. High-Pressure Homogenization: This technique uses high pressure to force the drug suspension through a narrow gap, resulting in particle size reduction. 2. Wet Milling: A milling process where drug particles are ground in the presence of surfactants. 3. Antisolvent Precipitation: A process where a drug solution is rapidly mixed with a nonsolvent, leading to precipitation of nanoparticles. 4. Emulsion Diffusion: Involves creating an emulsion and then removing the solvent, causing the drug to precipitate as nanoparticles.
