How Does Soft Corona Affect Nanoparticle Behavior?
The presence of a soft corona can alter the surface charge, hydrodynamic size, and aggregation state of nanoparticles. This, in turn, affects their circulation time in the bloodstream, their ability to evade the immune system, and their targeting efficiency. Additionally, the composition of the soft corona can modulate cellular recognition and internalization pathways, influencing the ultimate therapeutic efficacy or diagnostic accuracy of the nanoparticles.
