How Do We Overcome the Issue of Nanoparticle Clearance?
Once administered, nanoparticles face the challenge of being rapidly cleared from the body by the reticuloendothelial system (RES). This rapid clearance can significantly reduce the therapeutic efficacy of the nanocarriers. Strategies such as surface modification with polyethylene glycol (PEG) can help evade immune detection, but these methods are not always foolproof.
