instrumentation limitations:

How do current instruments fare against these challenges?

Despite these challenges, current instruments have made significant strides:
1. Atomic Force Microscopy (AFM): AFM offers high-resolution imaging and can operate in various environments, but it can be slow and often requires meticulous sample preparation.
2. Electron Microscopes: SEM and TEM provide excellent resolution but are expensive and require extensive training to operate.
3. Scanning Tunneling Microscopy (STM): STM can visualize and manipulate individual atoms, but it requires ultra-high vacuum conditions and low temperatures.

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