To address the risk of capillary clogging, several strategies can be employed:
Surface modification: Coating nanoparticles with biocompatible materials can reduce aggregation and improve their circulation time. Size optimization: Designing nanoparticles within the optimal size range (usually less than 200 nm) can minimize the risk of capillary obstruction. Shape control: Spherical nanoparticles are generally less likely to cause clogging compared to irregularly shaped ones.
