Monodisperse - Nanotechnology

What Does Monodisperse Mean?

In the context of nanotechnology, "monodisperse" refers to a collection of particles that are uniform in size and shape. This uniformity is crucial for a wide range of applications, as it ensures consistent behavior and properties. Monodispersity is typically contrasted with polydispersity, where particles vary significantly in size and shape.

Why is Monodispersity Important?

Monodisperse nanoparticles exhibit predictable and reproducible properties, such as optical, electronic, and catalytic behaviors. For instance, in drug delivery, monodisperse particles ensure consistent dosage and controlled release. In optics, uniform particle size is essential for minimizing scattering and maximizing the desired optical effects.

How is Monodispersity Achieved?

Achieving monodispersity involves precise control over the synthesis process. Techniques such as sol-gel methods, microemulsion, and seed-mediated growth are commonly used. These methods allow for the fine-tuning of parameters like temperature, concentration, and reaction time to produce uniform nanoparticles.

Applications of Monodisperse Nanoparticles

Monodisperse nanoparticles have a myriad of applications. In catalysis, uniform particle size ensures consistent catalytic activity. In medical imaging, monodisperse particles provide clearer images due to their uniform interaction with imaging agents. They are also used in electronics for the fabrication of highly efficient devices and in coatings for creating surfaces with specific properties.

Challenges and Solutions

One of the primary challenges in creating monodisperse nanoparticles is maintaining uniformity during scale-up. Small-scale laboratory conditions can be precisely controlled, but replicating these conditions in large-scale manufacturing can be difficult. Advanced techniques like flow chemistry and automated synthesis can help overcome these challenges by providing more consistent control over reaction conditions.

Future Prospects

The demand for monodisperse nanoparticles is expected to grow as they are pivotal in developing next-generation technologies. Innovations in synthesis techniques and characterization methods will likely make the production of monodisperse nanoparticles more efficient and cost-effective. The ongoing research aims to expand their applications in energy storage, environmental remediation, and advanced materials.

Relevant Publications

Impacts of polyethylene glycol (PEG) dispersity on protein adsorption, pharmacokinetics, and biodistribution of PEGylated gold nanoparticles.

Issue Release: 2024

Maintained particulate integrity of soy protein nanoparticles during gastrointestinal digestion via genipin crosslinking enhancing stability and bioavailability of curcumin.

Issue Release: 2024

Laronidase-loaded liposomes reach the brain and other hard-to-treat organs after noninvasive nasal administration.

Issue Release: 2024

Microfluidic production, stability and loading of synthetic giant unilamellar vesicles.

Issue Release: 2024

Monodisperse polyhydroxyalkanoate nanoparticles as self-sticky and bio-resorbable tissue adhesives.

Issue Release: 2024

Synthesis, characterization and stability of crosslinked chitosan-maltodextrin pH-sensitive nanogels.

Issue Release: 2024

The interaction of size-selected Ru clusters with TiO: depth-profiling of encapsulated clusters.

Issue Release: 2024

From Bioreactor to Bulk Rheology: Achieving Scalable Production of Highly Concentrated Circular DNA.

Issue Release: 2024

Risperidone-Loaded Nasal Thermosensitive Polymeric Micelles: Quality by Design-Based Formulation Study.

Issue Release: 2024

Surface Ammonium Ions Assisted Decoration of Monodisperse Cobalt Nanoparticles on Molybdenum Oxide Films as Efficient Electrocatalysts for Hydrogen Evolution Reaction.

Issue Release: 2024

Biochemical characterization of paralyzed flagellum proteins A (PflA) and B (PflB) from Helicobacter pylori flagellar motor.

Issue Release: 2024

Cytokine-induced killer cells-mediated chlorin e6-loaded gold nanostars for targeted NIR imaging and immuno-photodynamic combination therapy for lung cancer.

Issue Release: 2024

Gelatin maleimide microgels for hematopoietic progenitor cell encapsulation.

Issue Release: 2024

The Structural Dispersity of Oligoethylene Glycol-Containing Polymer Brushes Determines Their Interfacial Properties.

Issue Release: 2024

Wavenumber-dependent dynamic light scattering optical coherence tomography measurements of collective and self-diffusion.

Issue Release: 2024

Drug testing of monodisperse arrays of live microdissected tumors using a valved multiwell microfluidic platform.

Issue Release: 2024

De novo design of buttressed loops for sculpting protein functions.

Issue Release: 2024

CCR1 and CCR2 Coexpression on Monocytes Is Nonredundant and Delineates a Distinct Monocyte Subpopulation.

Issue Release: 2024

Monodisperse nanosheet mesophases.

Issue Release: 2024

Preparation of stable and monodisperse paclitaxel-loaded bovine serum albumin nanoparticles via intermolecular disulfide crosslinking.

Issue Release: 2024

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